The Department of Energy (DOE) Office of Science’s High Energy Physics and Nuclear Physics programs have supported research on antimatter for decades as part of DOE’s involvement in fundamental physics research. The Office of Nuclear Physics supports research to understand the asymmetry between matter and antimatter within its Fundamental Symmetries portfolio. This includes extremely sensitive table-top experiments using neutrons and nuclei and larger scale experiments hosted in deep underground laboratories looking for neutrinoless double beta decay, a predicted nuclear decay that would create two leptons without any accompanying antileptons thus creating more matter than antimatter. The Office of High Energy Physics (HEP) supports the Deep Underground Neutrino Experiment (DUNE) designed to detect neutrinos created at Fermi National Accelerator Lab. DUNE should be able to tell whether neutrinos are a major contributor to this asymmetry. HEP also supports experiments at high energy particle accelerators that search for differences between matter and antimatter in the decay of heavy particles created in high energy collisions.